Hypoxia upregulates carcinoembryonic antigen expression in cancer cells
نویسندگان
چکیده
منابع مشابه
Hypoxia upregulates Hsp90α expression via STAT5b in cancer cells.
Hsp90α is a molecular chaperone protein involved in the structural maturation of oncogenic signaling proteins. Hsp90 was recently identified as an anticancer target; various studies are ongoing to find ways for managing cancer through Hsp90α. However, this approach is limited by reported side-effects. Hypoxia is a hallmark of solid tumors, including those of breast cancer and the extent of tumo...
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متن کاملSerum Levels of Carcinoembryonic Antigen and a Tumor-extracted Carcinoembryonic Antigen-related Antigen in Cancer Patients1
Levels of Carcinoembryonic antigen (CEA) and a tumor-ex tracted CEA-related antigen (TEX) were determined in sera from patients with carcinomas of the breast, colon, lung, head and neck, and a number of miscellaneous categories. The purpose of this study was to compare the levels of each antigen at various stages of malignant disease. Competitive radioimmunoassays developed in our laboratory we...
متن کاملSerum levels of carcinoembryonic antigen and a tumor-extracted carcinoembryonic antigen-related antigen in cancer patients.
Levels of carcinoembryonic antigen (CEA) and a tumor-extracted CEA-related antigen (TEX) were determined in sera from patients with carcinomas of the breast, colon, lung, head and neck, and a number of miscellaneous categories. The purpose of this study was to compare the levels of each antigen at various stages of malignant disease. Competitive radioimmunoassays developed in our laboratory wer...
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Carcinoembryonic antigen (CEA) has been reported to promote the metastatic potential in some experimental tumors. Adhesion molecules are known to play an important role in the process of metastasis. Cytokines, including interleukin 1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), which are produced by Kupffer cells, induce endothelial cells to express adhesion molecules. As a resul...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2007
ISSN: 0020-7136,1097-0215
DOI: 10.1002/ijc.22965